NYU Data Catalog

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Results Found: 5
  • NYU Dataset

    Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

    Authors
    Maria M. Steele
    Ian D. Dryg
    Dhaarini Murugan
    Julia Femel
    6 more author(s)...
    Description

    CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...

    Subject
    Cancer
    Genomics
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    Author Approval Required
  • NYU Dataset

    Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in Non-Small Cell Lung Cancer

    Authors
    Kwan Ho Tang
    Shuai Li
    Alireza Khodadadi-Jamayran
    Jayu Jen
    14 more author(s)...
    Description

    SHP2 plays critical roles in normal cell signaling and SHP2 inhibitors alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. This study showed that inhibiting the SHP2/RAS/ERK pathway triggers upregulation of CXCR2 ligands. In this study, C57BL/6J mice were used as the orthotopic allograft lung cancer model. They injected KP cells into the...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    CXCR6 Promotes Dermal CD8+ T Cell Survival and Transition to Long-Term Tissue Residence

    Authors
    Taylor A. Heim
    Ziyan Lin
    Maria M. Steele
    Tenny Mudianto
    1 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...

    Subject
    Genomics
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    Author Approval Required
  • NYU Dataset

    Lymphatic Vessel Transit Seeds Precursors to Cytotoxic Resident Memory T Cells in Skin Draining Lymph Nodes

    Authors
    Taylor A. Heim
    Austin C. Schultz
    Ines Delclaux
    Vanessa Cristaldi
    2 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...

    Subject
    Genomics
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    Author Approval Required
  • NYU Dataset

    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Authors
    Ellie Ivanova
    Jasmine Shwetar
    Joseph C. Devlin
    Terkild B. Buus
    17 more author(s)...
    Description

    To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All